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Messages - SarahVaughter

1741
Dermarolling / Microneedling / MSM
« on: November 04, 2010, 09:57:32 AM »
Methylsulfonylmethane (MSM) is a sulfur compound. Sulfur is a mineral that is present in body proteins, especially in connective tissue. Keratin contains lots of sulfur. Keratin is present in the skin, nails and hair. The typical rubbery smell of burning hair comes from sulfur. MSM is a good source of organic sulfur.

 

If you are deficient in Sulfur, you will benefit from MSM supplementation.

   

  But deficiency is very unlikely in individuals who eat meat, milk products or vegetables.

   MSM is a small molecule and it penetrates the skin (and even the blood brain barrier) easily. MSM itself is used as a skin penetration enhancer – to facilitate the penetration of other substances. That is why it is not necessary to use dermarolling prior to its application.

     

  MSM is used for skin lightening and hyperpigmentation spots as a safer alternative to Hydroquinone.

   It is also used (usually orally) in osteoarthritis in combination with Glucosamin and Chondroitin for its anti-inflammatory and analgesic effects.

     

  Yes you can take MSM orally. Many studies have found MSM intake safe.

   

  Toxicity of Methylsulfonylmethane in rats:

     

  http://www.ncbi.nlm.nih.gov/pubmed/12387309

   

  Oral developmental toxicity study of methylsulfonylmethane in rats:

   

  http://www.ncbi.nlm.nih.gov/pubmed/17258373

     

  Nonetheless, I think that a healthy diet is the best source of Sulfur.

It is not true that food processing destroys Sulfur, for Sulfur is an element, and elements can only be transmutated by high-energy nuclear reactions. And even elemental Sulfur is well-absorbed.

1742
Dermarolling / Microneedling / what size roller is appropriate
« on: November 04, 2010, 07:35:11 AM »
The skin consists of 3 main layers: The epidermis, the dermis and the hypodermis. Acne scars are in the epidermis (the injury that caused the its atrophy is the scar). Acne scars reach various depths of the dermis. That is why you have to use a roller that reaches the dermis. Meaning that the needles should be longer than 0.5 mm.

   

  Try a 1 mm roller in combination with our custom made single needles. Single needling is the most intensive treatment for scars and you only needle the scar itself, not the skin around it.

   

  How to do single needling is explained in our instructions:

   

  http://dermaroller.owndoc.com/dermaroller-instructions.pdf

1743
Dermarolling / Microneedling / SRS Micro Meso Roller
« on: November 02, 2010, 06:04:39 AM »
They may hurt less (if you want to believe the marketing hype of a company that asks 130 dollars for a dermaroller..), but that would be because they don't work, in that case. If it doesn't hurt, the needles are either too thin or too short to cause significant collagen regeneration, because damage is required to trigger that, and causing that damage hurts. No pain, no gain. No magic bullets.

The Micro Meso roller is just one of those super-cheap Chinese dermarollers, sold as a "magical roller" ("doesn't hurt") by a Middle Eastern company with a presence in Asia. I admire their chutzpah, asking 130 bucks for a run-of-the-mill Chinese-produced, throwaway-after-use roller costing perhaps two or three dollars to produce. Knowing the off-factory bulk prices, I would be very surprised if they pay more than five, six dollars a piece for that roller (can be seen in the below demonstration in Tel Aviv):

http://www.youtube.com/watch?v=D5h48FkRHRI

It is most definitely not produced in France or Belgium, as alleged here:

http://www.essentialdayspa.com/forum/viewthread.php?p=6393519

We have tested a lot of rollers and that always involves buying them from the factory, as we don't deal with retailers asking 130 dollars of course.

ALL rollers are made in China or Korea, period. Anyone telling you their roller is made in the US or Europe is a liar.

UPDATE 1:

I paused the YouTube clip seen here and had a close look at that roller. Look at its handle.. It is the roller that was so bad that it did not even made the entry requirements of our dermaroller test!



http://www.owndoc.com/dermarolling/dermaroller-review/

(It's the roller that penetrated its packaging - I assume that for $130,- they've changed their packaging now - but obviously not the roller..)

That roller is pictured in our test, above the text:  "One was “dead on arrival”: Its needles had penetrated the blister  packaging and some were bent. We found that the needles were of  textile-grade steel instead of surgical steel, and the handle was too  flexible to apply constant pressure."

That "Meso Roller" is clearly distinguished from other rollers by its badly designed handle. You can also recognize it by its large circular sides. It's the worst roller we ever saw:

Note that our initial test is about a year old. I'd say that so far, this "Meso roller" is the biggest scam we've seen in the dermarolling world. There really is only one roller with such handle shape. It is particularly simplistic and badly designed, not ergonomical and too thin, so that it bends. For 130 dollars you can buy a year's supply of top-of-the line dermarollers, including ointments, vitamins and single needles. I am amazed at how clever, very expensive marketing can make people pay 130 dollars for something that should cost at best 13 dollars. We are doing it the opposite way. We do not do any marketing. Nothing. That's how we can afford to remain honest, get a lot of word-of-mouth and don't have to recoup excessive marketing cost by selling cheap crap at an outrageous premium.

UPDATE 2:

Just to be sure that apart from the "SRS" print on the handle, we're talking about the same dermaroller here, I went to the SRS site and sure enough, it's that same roller with the too thin handle and the chunky, squarish mount for the roller head:

(Photo made by Assaf Zeira in Israel - he asked us to take the picture down but it is used in fair use)



That generic lowest-quality roller is re-branded offered by more companies, such as "Dermal Integrity". They always ask an outrageous price for it (Dermal Integrity wants 150 dollars..) and claim all kinds of nonsense, such as FDA approval and US origin. Look at the shape of the handle where it is attached to the roller head holder and you can recognize this inferior roller. I mention again that we purchased this roller from its Chinese factory for less than five dollars!

UPDATE 3:

To back up my assertion that this SRS company is not French or Belgian, here are its registration details:

http://www.betterwhois.com/bwhois.cgi?domain=srs-solution.com&x=0&y=0

The company is owned by the (assumedly) Lebanese Mr. Elias Chabtini and he currently lives in Asia (Singapore):

Mr. Elias has been selling beauty-related products all over the Middle East, including Kuwait. Nothing European about that company.

                      Attached files      

1744
Yes you can use vit. E and cocoa butter but before your roll, pre-treat your skin with vit. C since it is essential for collagen synthesis.

If your skin is dry you can also use coconut butter.

  Btw coconut butter is one of very few oils that can penetrate into the hair shaft, so you can also apply it to the tips of your hair as an excellent hair conditioner. Apply it several hours before you plan to wash your hair. Then wash it off. If you hair is very frizzy, you can use it as a "leave on" conditioner.

    Coconut butter does not contain any cholesterol and can be used for frying.

1745
Dermarolling / Microneedling / Vitamin A cream toxicity?
« on: October 28, 2010, 10:55:51 AM »
> Is infadolan toxic if it gets in your blood stream when you

> use it with dermaroller there's topic's and youtube video's

> talking about certain vitamin a, c and others just curious.      



Vit. A

   "Acute toxic dose is 25,000 IU/kg, and chronic toxic dose is 4000 IU/kg every day for 6-15 months.”

 

  http://emedicine.medscape.com/article/819426-overview

  Our 30-gram tubes of Infadolan  contain in total 48,000 IU Retinyl acetate per tube.



For acute toxicity, an individual weighing 50 kg would have to eat 26 tubes of Infadolan in one go.


 

  For chronic toxicity, an individual weighing 50 kg would have to eat four tubes of Infadolan daily for 6 months to 15 months.

 

However you should not use Infadolan or other vit. A creams or ointments on extensive areas after dermarolling when pregnant.


 

 

 

11. Toxicological information   (tested by BASF)

  Acute toxicity

 

  Information on: Retinyl acetate

 

  Assessment of acute toxicity:

 

  Virtually nontoxic after a single ingestion.

 

  ----------------------------------

 

  Oral:

 

  Information on: retinyl acetate

 

  Type of value: LD50

 

  Species: rat

 

  Value: > 2,000 mg/kg (BASF-Test)

 

http://www.owndoc.com/pdf/vit-a-toxicity.pdf

1746
I suffered from Acne many years. Now the ISO-Therapie (Ciscutan) is over. (Since 6 Months)

   But I still have a lot of big-sized pores (like tiny holes) and scars (some are red) in my face.

     But that´s not enough: I´ve also a big number of stretchmarks around the hips, bottom and some on the back. That´s becaue of lifting weights. (My skin wasn´t flexible enough for the pressure)

     So I decided to give the microneedling a chance for both of my problems. I have read your articles and now I have a few questions:

     - I think the 1,5 mm roller would be the best option. I want to use the Emla Cream to numb the skin. You said it´s not good for large areas.. what is large? Can I numb my whole face in one go or should I do this in several parts?

   I thought I would numb and roll the face in one go and the stretchmarks one week later.... so my skin must nor absorb to much emla-cream in to short time. Is that a good idea or are the skin-areas still to big?

     -I still have 2-3 "spots" in my face. But no inflammations. The spots are more like little warts? Is that a problem for microneedling?  

     - How long does it take to have normal-looking skin after rolling. I can only do this on friday evening. So It kan take 2 days to heal because of my job.

     -What preperates do I really need - before and after? (vit A,B,C,D...) Is the "Copper peptide facial mask" essential? I think the other preperates are "must-haves". Is that right?

     -How many preperates do I need for approximately 1 to 1.5 years?

     -Please send me a list of what I really need and how to use it. Then I´m going to buy the whole stuff in your shop.

 

    Acne scars usually respond well to rolling/needling but unfortunately almost nothing fixes enlarged pores and if yes, the result is only temporary. Pores are ducts in the skin with sebaceous glands and there are basically no methods to make pores smaller. You can only improve scars.

 

Indeed, 1.5 mm is a good option. The skin on the back and buttocks is one of the thickest on the body.  

 

You can numb your face in one go – no problem.  You do not have to wait one week with numbing your stretch marks area. There will be no EMLA present in your body the next day.


 

  “Elimination:- The half-life of lidocaine elimination from the plasma following IV administration is approximately 65 to 150 minutes (mean 110, ±24 SD, n=13). More than 98% of an absorbed dose of lidocaine can be recovered in the urine as metabolites or parent drug. The systemic clearance is 10 to 20 mL/min/kg (mean 13, ±3 SD, n=13). The elimination half-life of prilocaine is approximately 10 to 150 minutes (mean 70,

  ±48 SD, n=13). The systemic clearance is 18 to 64 mL/min/kg (mean 38, ±15 SD, n=13)."

 

http://www1.astrazeneca-us.com/pi/EMLA.pdf


 

  The stated half-life means that if some of EMLA gets absorbed into the blood, the amount of EMLA in the blood will halve every 65 to 150 minutes until there is nothing left.

 

The spots on your face (the little warts you speak of) present no problem for dermarolling.

About how long it will take to have normal-looking skin after dermarolling:    



  If you roll with 1.5 mm the skin will look like you have got mild sunburn. This usually lasts only for a few hours. The skin will be vulnerable and drier for couple of days and you should keep it moisturized and protected from UV by sunscreen lotion.  

 If you do single needling (which is the most targeted and intensive method for scars) the redness may last several days. You can single-needle every couple of days one or two scars so that you do not have many red spots on your face in one go.



  Just do a test patch on one scar and you will see how long the redness will last. It also depends how deeply and densely you needle.

 

About what vitamins etc. you need:  

 

Copper peptides are not essential. Vit. C is because it is necessary for collagen synthesis.

For a treatment duration of one to one and a half years, you will need:



  -two 1.5 mm dermarollers (you can also try with one, and switch to 2 mm later)



  -one pack of single needles (one pack contains 5 needles. If you intend to use them regularly, you'll need more)

 

-four 20-gram bags of vit. C powder


 

-one Infadolan – use it especially on your stretch marks after rolling / needling


 

-one tube of EMLA – you will probably be able to roll without EMLA. The face is quite painful to roll but it is bearable, the hips and around the hip area can be rolled without EMLA.


 

This will last you a long time. If you get no occasional pinpoint bleeding with 1.5 mm on your back/hips/buttocks you can even opt for a 2 mm roller with your next purchase. Our postage fees are very low so you can always order things separately.


Then read our detailed microneedling instructions:

  http://dermaroller.owndoc.com/dermaroller-instructions.pdf

Some more about EMLA:

   The tube we sell contains 30 g EMLA. The studies using 60 g EMLA applied to 400 cm2 of intact skin and left occluded for 3 and 24 hours did not end up in toxic blood levels.  But you must remove EMLA before you roll because rolling highly enhances the absorption of anything applied.

 



  “Absorption: The amount of lidocaine and prilocaine systemically absorbed from EMLA Cream is directly related to both the duration of application and to the area over which it is applied. In two pharmacokinetic studies, 60 g of EMLA Cream (1.5 g lidocaine and 1.5 g prilocaine) was applied to 400 cm2 of intact skin on the lateral thigh and then covered by an occlusive dressing. The subjects were then randomized such that one-half of the subjects had the occlusive dressing and residual cream removed after 3 hours, while the remainder left the dressing in place for 24 hours. The results from these studies are summarized below.

 

  When 60 g of EMLA Cream was applied over 400 cm2 for 24  hours, peak blood levels of lidocaine are approximately 1/20 the systemic toxic level. Likewise, the maximum prilocaine level is about 1/36 the toxic level.

 

  The application of EMLA Cream to broken or inflamed skin, or to 2,000 cm2 or more of skin where more of both anesthetics are absorbed, could result in higher plasma levels that could, in susceptible individuals, produce a systemic pharmacologic response.”

                      Attached files

1747
Both can be used on your neck or anywhere on the body except for the upper eyelids.

   

  To trigger collagen production, you have to reach the dermis – for that use a 1 mm roller.

1748
Dermarolling / Microneedling / Infadolan and pregnant women
« on: October 25, 2010, 04:27:07 PM »
The risk of overdosing vit. A is associated with oral intake. Only a small quantity of Infadolan is used after rolling and only a small percentage gets into the bloodstream (if at all). The producer of Infadolan states it can be used in pregnancy, but of course that is with intact skin.

   However for peace of mind, it is better not to use Infadolan on extensive areas of skin right after dermaneedling  during pregnancy.

   You can use a dermaroller during pregnancy but only if it is not unpleasant for you (painful etc) since all stress should be avoided during pregnancy.

   

  If you roll with long needles, there is a small risk of infection if improperly disinfected, which should be also avoided during pregnancy.

   

  You should always keep in mind that dermarolling will highly enhance the absorption of the skin products and some of it may get into the bloodstream. If you apply an antibiotic cream, some of it may get into your blood stream as well. The amount will be minuscule but for peace of mind it is probably the best to avoid it, in pregnancy.

1749
Dermarolling / Microneedling / Dermarolling/Needling While on Accutane?
« on: October 25, 2010, 04:24:14 PM »
Accutane treatment affects wound healing and increases the risk of delayed healing and hypertrophic scarring.

  This doesnt mean that everybody on Accutane will always get scars after ablative procedures. It only means that the risk  of getting scars or delayed healing is increased.

  Ablative methods such as Laser resurfacing or chemical peels or plastic surgery should be avoided within six months to two years of having stopped taking Accutane.

  Dermarolling is not an ablative treatment (it doesn't remove the epidermis). Nevertheless, you should wait at least six months after taking the last dose of Accutane. Always do a small test patch first to see how it heals.

  It is said that when the oiliness returns to the facial skin, it is safe to start with Laser or other procedures.

  I am glad you asked because I realize we have to add this to our dermarolling instructions!

1750
Dermarolling / Microneedling / LED skin treatment
« on: October 25, 2010, 10:33:21 AM »
>Also, do you have any expertise on LED therapy?

   

  It might improve active acne or Rosacea but not the depth of any scars.

  Lots of people claim it did nothing for their pores. Example:

   

  http://www.smartskincare.com/forum/viewtopic.php?t=4006

   

  I cannot comment on the efficacy of LEDs, I will just write some information to help you make a choice.

   

  Low-power laser therapy and also LED (light-emitting diode)  therapy has been used with various success to relieve certain kind of musculoskeletal pain, chronic inflammation and to speed up the healing of soft tissue or ischemic injuries.

   

  Concerning the skin, there are claims that light treatment with LEDs can modulate fibroblast proliferation and collagen synthesis.

   

  The mechanism of its biological effects is not fully understood.

   

  It is believed that a primary effect is the stimulation of mitochondrial oxidative cell metabolism and thus accelerating cell- and tissue repair.

   

  The most common outcomes in successful cases are the reduction of redness, improved skin tone and enhanced skin smoothness.

   

  Blue LEDs supposedly negatively affect acne bacteria (if the claims are true, perhaps because blue light is close to the sterilizing UV-A) but they do not affect the depth of acne scars. Sunlight should have the same or even better effect as blue LEDs.

   

  Red LEDs reduce redness such as from inflammation. Red light displays anti-inflammatory properties by influencing cytokine release from macrophages. Sometimes it is used to hasten the reduction of redness for example, after treatment with IPL (intense pulse light), acid peels or Fraxel Laser. Again, this effect can simply be due to the fact that red light is close to infrared, which is heat. So again, ordinary sunlight may yield an even better result.

   

  How to choose a LED device:

   

Assuming you buy into the hype. If you plan to use it on large skin areas such as the whole face etc, buy a device that has many LEDs and covers a large area of skin in one go. This will significantly shorten the time necessary for treating large areas.

   

  Frequently used wavelengths:

   

  Blue light between 400 nm to 412 nm is most commonly used to treat acne, sometimes in combination with infrared (wavelengths of 830 nm to 880 nm).

   

  Red light at around 633 nm - 660 nm for inflammation reduction and skin smoothness.

   

  Yellow light: The GentleWaves device emits a 590 nm wavelength. They are spending a fortune in TV advertizing to claim "NASA technology" but we do not know of any clinical evidencethat it does anything.

   

  Lots of devices use the combination of blue and red/infrared LEDs.

   

  Hold the LED device very close to the skin. The closer the better. A LED (light emitting diode) does not emit much heat (except for a little infrared). Clean your skin prior to treatment. Eye protection is not necessary, because even though Laser LEDs do exist, LED skin therapy is done with "ordinary light" LEDs, meaning the same effect (if there really is any) can theoretically be achieved with an ordinary light bulb with a colored filter.

  You should administer a dose of at least 4 Joules per cm2 of skin per treatment in order to achieve the smallest of effects.



  Example:

   

  A LED device has these specifications:

   

  Red (wavelength 633 nm). Power output 8.4 mW/cm2. A mW is a milliWatt, or a thousandth of a Watt.

   

  The light output is 8.4 mW per cm2 and your goal is 4 Joules per cm2 per treatment. One Joule is defined as one Watt per second, so in order to achieve that, you should know that J = W x S (Joule is Watt x Seconds)

   

  In our case, we want to know how many seconds, so our equation becomes S = J / W. We just said 4 Joules is the target energy to be delivered to a square centimeter of skin, and the output of LED devices is stated in mW, so the formula to use is: Seconds of treatment per cm2 of skin = 4000 mJ / milliWatt per cm2 of skin.

   

  4000 mJ divided by 8.4 = 476 seconds.

   

  So each time you use the device, you should apply it for 476 seconds (8 minutes) on a skin surface area with the same size as the light emitting surface area as the device. This means that if you want to treat a skin area that is four times larger than the light emitting part of the LED device, that you need to move it over the skin for 4 x 8 = 32 minutes in total.

   

  If the output per cm2 is not specified, look for the total output of the device and divide the total output by the total area of the panels with LEDs. This will give the Wattage per cm2. Example: Output area is 10 cm2, total Wattage is 50 mW. Wattage per cm2 is 50 divided by 10 = 5 mW.

   A bare minimum of 4 Joules per cm2 per treatment is required to attain any kind of biological effect. To give you an idea how many doses were used during studies:

   

 

Blue and Red Light Combination LED Phototherapy for Acne Vulgaris in Patients with Skin Phototype IV


   

  The blue light comprised of five panels containing 260 LEDs each.

 

The red light consisted of four panels containing 420 LEDs each.

 

The treatment heads delivered wavelengths:

 

415.5 nm for the blue light and 633.6 nm for the red light.

 

The irradiance was 40 mW / cm2 for the blue light and 80 mW / cm2 for the red light at a distance of 1–10 cm from the light source.

The radiant fluences, or doses, during a single treatment for 20 minutes were 48 and 96 J/cm2 for the blue and red treatment heads, respectively alternating blue (415 nm) and red (633 nm) light.

The treatment was performed twice a week for four weeks:

   

  http://www.huidzaak.nl/publicaties/acne/127%20Lee%20et%20al-Blue%20and%20red%20light%20combination%20LED%20phototherapy%20for%20acne%20vulgaris%20in%20patients%20with%20skin%20phototype%20IV.pdf

   

  Combination blue (415 nm) and red (633 nm) LED phototherapy in the treatment of mild to severe acne vulgaris

   

  Subjects were treated in eight sessions, two per week, 3 days apart, alternating between 415 nm blue light (20 minutes per session, 48 J/cm2) and 633 nm red light (20 minutes per session, 96 J/cm2) from a light-emitting diode (LED)-based therapy system.

   

  http://www.skinandlasers.com/asp/UpLoad/publication/Combination%20Blue%20and%20Red%20LED%20phototherapy%20in%20the%20treatment%20o.pdf

   

   

  A study to determine the efficacy of combination LED light therapy (633 nm and 830 nm) in facial skin rejuvenation:

   

  http://www.ncbi.nlm.nih.gov/pubmed/16414908

   

  The treatments combined wavelengths of 633 nm and 830 nm with fluences of 126 J/cm2 and 66 J/cm2.

   

  As you see, the small "home" treatment devices have an output that is really much to small to achieve the results they speak of in clinical trials. Unless there emerges evidence that those devices work better than for example equivalent bursts of sun exposure, I would stick to micro-needling.

1751
Dermarolling / Microneedling / Vitamin C serum consistency
« on: October 24, 2010, 09:36:56 AM »
No, it should have the consistency of water.

1752
Dermarolling / Microneedling / Saline injections for acne scars
« on: October 22, 2010, 11:28:21 AM »
It is hard to give advice because so very few doctors use this cheap method so there is no relevant statistical data or recommendations on how to combine it with another method such as dermarolling. There is evidence that saline injections do work, especially for rolling acne scars but just like dermarolling, it works gradually - you have to do it repeatedly to see results.

   

I would recommend you to needle the scars (from different angles and to various depths) prior to saline injections to crush the hardened collagen, let it heal fully and then have the saline injections every two weeks (without needling).

   

  Alternatively, roll/needle immediately before saline injections to form a “pocket” under the scar, for the saline solution to reside in.

  The saline injections should be placed underneath the scar, where the scar is attached to the tissue.

   

  You could also improvise a suction method such as the one Lainey described in the post above or here:

   http://forums.owndoc.com/dermarolling-microneedling/Subcision-suction-method-for-acne-scars /a>

 

   

  Basically you will have to experiment a little to discover what works best. Do a test scar first.

   I wrote about another cheap and interesting method:

   

  http://forums.owndoc.com/dermarolling-microneedling/Autologous-(own)-blood-injection-for-acne-scars-or-atrophic-scars

1753
Dermarolling / Microneedling / getting stretchmarks on my face
« on: October 22, 2010, 09:06:20 AM »
I'm glad you finally found out what the problem is, because that is the first step to succesful treatment/prevention/cure.

1754
Autologous blood injection is a method of using the body's own cells to help repair scars. It is effective if repeatedly done.

   Blood is taken from the patient and immediately reinjected precisely into acne/atrophic scars. This procedure is repeated every month until improvement is achieved. Sometimes the blood is centrifuged and platelet-rich plasma is used (this method is more expensive). The resulting hematoma stimulates the extracellular matrix repair. A hematoma is a signal for the body that there is damage and it has to be fixed. Blood has valuable components such as growth factors, peripheral blood stem cells and other cells essential for cellular regulation and repair.

   The blood is injected into the scar and either it is left alone or the hematoma is used as a target for a vascular laser or IPL.  Lasers, in skin treatment work because some skin structures strongly absorb certain wavelengths of light. This light energy is converted to heat, which causes damage to the targeted cells without damaging the surrounding tissue.

Laser treatment for hair reduction targets Melanin in the hair follicle, vascular laser targets Oxyhemoglobin in red blood cells. Treating the hematoma with a vascular laser heats up the scar and further stimulates the remodeling of tissue.

   

Sometimes a subcision is performed prior to injecting the blood. Subcison is a method where a syringe is placed horizontally underneath the scar and moved in order to sever the fibrous bands that are holding the scar down. Subcision also provides a pocket for the injected blood so that more blood can be injected.

(Rolling and especially needling functions as a vertical subcision. It cuts the fibrous septae and severs the scar's deep attachments)

   

The advantage of this procedure is that it is easy to perfom, does not cost much in materials and the results should be long-lasting. Since the blood injected is the patient's own, there is no risk of an allergic reaction.

   

Other autologous fillers have been used for skin augmentation – own fat, own collagen, own fibroblasts etc. They are safe and effective but in comparison to blood injections they are much more expensive.

    Synthetic fillers, especially long lasting ones, carry a risk of granuloma formation.

1755
Dermarolling / Microneedling / Making Vitamin C , should i use glycerin?
« on: October 21, 2010, 04:42:02 AM »
You can apply it how you prefer, even with your bare hands, after having washed your hands.